For an oocyte to be ready for fertilization and growth into an embryo, the ideal set of genes has to be turned on. Namekawa suspected that this pre-programming with the oocyte genome happens in numerous levels — the first one particular beginning throughout the time a woman is born. He believed that chromatin remodeling proteins did much of this operate, by shifting spools all over.
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“The organization of chromatin influences which genes is often expressed,” says Namekawa. That’s for the reason that the specific places from the spools, as well as the spacing among them, determines which stretches of DNA may be accessed by molecules termed transcription variables, which latch on to genes and switch them on.
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